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Imaging of Mesenteric Ischemia

Variant: 1   Suspected acute mesenteric ischemia. Initial imaging.
Procedure Appropriateness Category Relative Radiation Level
CTA abdomen and pelvis with IV contrast Usually Appropriate ☢☢☢☢
US duplex Doppler abdomen May Be Appropriate O
Radiography abdomen May Be Appropriate ☢☢
Arteriography abdomen May Be Appropriate (Disagreement) ☢☢☢
MRA abdomen and pelvis without and with IV contrast May Be Appropriate (Disagreement) O
CT abdomen and pelvis with IV contrast May Be Appropriate ☢☢☢
MRA abdomen and pelvis without IV contrast Usually Not Appropriate O
CT abdomen and pelvis without IV contrast Usually Not Appropriate ☢☢☢
CT abdomen and pelvis without and with IV contrast Usually Not Appropriate ☢☢☢☢

Variant: 2   Suspected chronic mesenteric ischemia. Initial imaging.
Procedure Appropriateness Category Relative Radiation Level
MRA abdomen and pelvis without and with IV contrast Usually Appropriate O
CTA abdomen and pelvis with IV contrast Usually Appropriate ☢☢☢☢
US duplex Doppler abdomen May Be Appropriate O
Arteriography abdomen May Be Appropriate (Disagreement) ☢☢☢
MRA abdomen and pelvis without IV contrast May Be Appropriate O
CT abdomen and pelvis with IV contrast May Be Appropriate ☢☢☢
Radiography abdomen Usually Not Appropriate ☢☢
CT abdomen and pelvis without IV contrast Usually Not Appropriate ☢☢☢
CT abdomen and pelvis without and with IV contrast Usually Not Appropriate ☢☢☢☢

Panel Members
Summary of Literature Review
Introduction/Background
Pathophysiology
Discussion of Procedures by Variant
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
A. Radiography Abdomen
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
B. CTA Abdomen and Pelvis
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
C. CT Abdomen and Pelvis
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
D. MRA Abdomen and Pelvis
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
E. Arteriography Abdomen
Variant 1: Suspected acute mesenteric ischemia. Initial imaging.
F. US Duplex Doppler Abdomen
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
A. Radiography Abdomen
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
B. US Duplex Doppler Abdomen
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
C. CTA Abdomen and Pelvis
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
D. CT Abdomen and Pelvis
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
E. MRA Abdomen and Pelvis
Variant 2: Suspected chronic mesenteric ischemia. Initial imaging.
F. Arteriography Abdomen
Summary of Recommendations
Summary of Evidence
Supporting Documents

The evidence table, literature search, and appendix for this topic are available at https://acsearch.acr.org/list. The appendix includes the strength of evidence assessment and the final rating round tabulations for each recommendation.

For additional information on the Appropriateness Criteria methodology and other supporting documents, please go to the ACR website at https://www.acr.org/Clinical-Resources/Clinical-Tools-and-Reference/Appropriateness-Criteria.

Appropriateness Category Names and Definitions

Appropriateness Category Name

Appropriateness Rating

Appropriateness Category Definition

Usually Appropriate

7, 8, or 9

The imaging procedure or treatment is indicated in the specified clinical scenarios at a favorable risk-benefit ratio for patients.

May Be Appropriate

4, 5, or 6

The imaging procedure or treatment may be indicated in the specified clinical scenarios as an alternative to imaging procedures or treatments with a more favorable risk-benefit ratio, or the risk-benefit ratio for patients is equivocal.

May Be Appropriate (Disagreement)

5

The individual ratings are too dispersed from the panel median. The different label provides transparency regarding the panel’s recommendation. “May be appropriate” is the rating category and a rating of 5 is assigned.

Usually Not Appropriate

1, 2, or 3

The imaging procedure or treatment is unlikely to be indicated in the specified clinical scenarios, or the risk-benefit ratio for patients is likely to be unfavorable.

Relative Radiation Level Information
References
1. Acosta S, Wadman M, Syk I, Elmstahl S, Ekberg O. Epidemiology and prognostic factors in acute superior mesenteric artery occlusion. J Gastrointest Surg. 2010; 14(4):628-635.
2. Herbert GS, Steele SR. Acute and chronic mesenteric ischemia. [Review] [66 refs]. Surgical Clinics of North America. 87(5):1115-34, ix, 2007 Oct.Surg Clin North Am. 87(5):1115-34, ix, 2007 Oct.
3. Kassahun WT, Schulz T, Richter O, Hauss J. Unchanged high mortality rates from acute occlusive intestinal ischemia: six year review. Langenbecks Arch Surg. 2008;393(2):163-171
4. Schoots IG, Koffeman GI, Legemate DA, Levi M, van Gulik TM. Systematic review of survival after acute mesenteric ischaemia according to disease aetiology. Br J Surg. 2004;91(1):17-27
5. Sreenarasimhaiah J. Chronic mesenteric ischemia. Best Pract Res Clin Gastroenterol. 2005; 19(2):283-295.
6. Angle JF, Nida BA, Matsumoto AH. Managing mesenteric vasculitis. [Review]. Techniques in Vascular & Interventional Radiology. 18(1):38-42, 2015 Mar.Tech Vasc Interv Radiol. 18(1):38-42, 2015 Mar.
7. Gumus H, Gumus M, Tekbas G, et al. Clinical and multidetector computed tomography findings of patients with median arcuate ligament syndrome. Clin Imaging. 2012;36(5):522-525
8. Min SI, Yoon KC, Min SK, et al. Current strategy for the treatment of symptomatic spontaneous isolated dissection of superior mesenteric artery. J Vasc Surg. 2011;54(2):461-466.
9. Woodhams R, Nishimaki H, Fujii K, Kakita S, Hayakawa K. Usefulness of multidetector-row CT (MDCT) for the diagnosis of non-occlusive mesenteric ischemia (NOMI): assessment of morphology and diameter of the superior mesenteric artery (SMA) on multi-planar reconstructed (MPR) images. Eur J Radiol. 2010; 76(1):96-102.
10. Al-Thani H, El-Mabrok J, El-Menyar A, et al. Clinical presentation and outcome of mesenteric vein thrombosis: a single-center experience. Angiology. 2015;66(3):249-256.
11. Kumar S, Sarr MG, Kamath PS. Mesenteric venous thrombosis. N Engl J Med. 2001;345(23):1683-1688
12. Cangemi JR, Picco MF. Intestinal ischemia in the elderly. Gastroenterol Clin North Am. 2009; 38(3):527-540.
13. Karkkainen JM, Lehtimaki TT, Manninen H, Paajanen H. Acute Mesenteric Ischemia Is a More Common Cause than Expected of Acute Abdomen in the Elderly. J Gastrointest Surg. 19(8):1407-14, 2015 Aug.
14. Lehtimaki TT, Karkkainen JM, Saari P, Manninen H, Paajanen H, Vanninen R. Detecting acute mesenteric ischemia in CT of the acute abdomen is dependent on clinical suspicion: Review of 95 consecutive patients. Eur J Radiol. 2015;84(12):2444-2453
15. Cudnik MT, Darbha S, Jones J, Macedo J, Stockton SW, Hiestand BC. The diagnosis of acute mesenteric ischemia: A systematic review and meta-analysis. Acad Emerg Med. 2013;20(11):1087-1100
16. Lyon C, Clark DC. Diagnosis of acute abdominal pain in older patients. Am Fam Physician. 2006; 74(9):1537-1544.
17. Gans SL, Stoker J, Boermeester MA. Plain abdominal radiography in acute abdominal pain; past, present, and future. Int J Gen Med. 2012;5:525-533
18. Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med. 2004;164(10):1054-1062
19. Wolf EL, Sprayregen S, Bakal CW. Radiology in intestinal ischemia. Plain film, contrast, and other imaging studies. Surg Clin North Am. 1992; 72(1):107-124.
20. Angelelli G, Scardapane A, Memeo M, Stabile Ianora AA, Rotondo A. Acute bowel ischemia: CT findings. Eur J Radiol. 2004; 50(1):37-47.
21. Wadman M, Syk I, Elmstahl B, Ekberg O, Elmstahl S. Abdominal plain film findings in acute ischemic bowel disease differ with age. Acta Radiol 2006; 47(3):238-243.
22. American College of Radiology. ACR–NASCI–SIR–SPR Practice Parameter for the Performance and Interpretation of Body Computed Tomography Angiography (CTA). Available at: https://gravitas.acr.org/PPTS/GetDocumentView?docId=164+&releaseId=2.
23. Barmase M, Kang M, Wig J, Kochhar R, Gupta R, Khandelwal N. Role of multidetector CT angiography in the evaluation of suspected mesenteric ischemia. European Journal of Radiology. 80(3):e582-7, 2011 Dec.Eur J Radiol. 80(3):e582-7, 2011 Dec.
24. Horton KM, Fishman EK. Multidetector CT angiography in the diagnosis of mesenteric ischemia. Radiol Clin North Am. 2007; 45(2):275-288.
25. Kirkpatrick ID, Kroeker MA, Greenberg HM. Biphasic CT with mesenteric CT angiography in the evaluation of acute mesenteric ischemia: initial experience. Radiology. 2003; 229(1):91-98.
26. Shih MC, Angle JF, Leung DA, et al. CTA and MRA in mesenteric ischemia: part 2, Normal findings and complications after surgical and endovascular treatment. AJR. 2007; 188(2):462-471.
27. Turkbey B, Akpinar E, Cil B, Karcaaltincaba M, Akhan O. Utility of multidetector CT in an emergency setting in acute mesenteric ischemia. Diagn Interv Radiol. 2009; 15(4):256-261.
28. White CJ. Chronic mesenteric ischemia: diagnosis and management. [Review]. Progress in Cardiovascular Diseases. 54(1):36-40, 2011 Jul-Aug.Prog Cardiovasc Dis. 54(1):36-40, 2011 Jul-Aug.
29. Schaefer PJ, Pfarr J, Trentmann J, et al. Comparison of noninvasive imaging modalities for stenosis grading in mesenteric arteries. Rofo. 2013;185(7):628-634.
30. Raman SP, Fishman EK. Computed Tomography Angiography of the Small Bowel and Mesentery. [Review]. Radiol Clin North Am. 54(1):87-100, 2016 Jan.
31. Aschoff AJ, Stuber G, Becker BW, et al. Evaluation of acute mesenteric ischemia: accuracy of biphasic mesenteric multi-detector CT angiography. Abdom Imaging. 2009;34(3):345-357
32. Wasnik A, Kaza RK, Al-Hawary MM, Liu PS, Platt JF. Multidetector CT imaging in mesenteric ischemia--pearls and pitfalls. Emerg Radiol. 2011;18(2):145-156
33. Hagspiel KD, Flors L, Hanley M, Norton PT. Computed tomography angiography and magnetic resonance angiography imaging of the mesenteric vasculature. [Review]. Tech Vasc Interv Radiol. 18(1):2-13, 2015 Mar.
34. Klar E, Rahmanian PB, Bucker A, Hauenstein K, Jauch KW, Luther B. Acute mesenteric ischemia: a vascular emergency. Dtsch Arztebl Int. 2012;109(14):249-256.
35. Ofer A, Abadi S, Nitecki S, et al. Multidetector CT angiography in the evaluation of acute mesenteric ischemia. Eur Radiol. 2009;19(1):24-30.
36. Chen YC, Huang TY, Chen RC, et al. Comparison of Ischemic and Nonischemic Bowel Segments in Patients With Mesenteric Ischemia: Multidetector Row Computed Tomography Findings and Measurement of Bowel Wall Attenuation Changes. Mayo Clinic Proceedings. 91(3):316-28, 2016 Mar.
37. Acosta S, Bjornsson S, Ekberg O, Resch T. CT angiography followed by endovascular intervention for acute superior mesenteric artery occlusion does not increase risk of contrast-induced renal failure. Eur J Vasc Endovasc Surg. 2010;39(6):726-730.
38. Clair DG, Beach JM. Mesenteric Ischemia. N Engl J Med. 2016;374(10):959-968.
39. Menke J. Diagnostic accuracy of multidetector CT in acute mesenteric ischemia: systematic review and meta-analysis. Radiology. 2010;256(1):93-101.
40. Wadman M, Block T, Ekberg O, Syk I, Elmstahl S, Acosta S. Impact of MDCT with intravenous contrast on the survival in patients with acute superior mesenteric artery occlusion. Emerg Radiol. 2010;17(3):171-178.
41. Yikilmaz A, Karahan OI, Senol S, Tuna IS, Akyildiz HY. Value of multislice computed tomography in the diagnosis of acute mesenteric ischemia. Eur J Radiol. 2011;80(2):297-302.
42. Schieda N, Fasih N, Shabana W. Triphasic CT in the diagnosis of acute mesenteric ischaemia. Eur Radiol. 2013;23(7):1891-1900.
43. Blachar A, Barnes S, Adam SZ, et al. Radiologists' performance in the diagnosis of acute intestinal ischemia, using MDCT and specific CT findings, using a variety of CT protocols. Emerg Radiol. 2011;18(5):385-394.
44. Gaa J, Laub G, Edelman RR, Georgi M. [First clinical results of ultrafast, contrast-enhanced 2-phase 3D-angiography of the abdomen]. Rofo. 1998;169(2):135-139
45. Gilfeather M, Holland GA, Siegelman ES, et al. Gadolinium-enhanced ultrafast three-dimensional spoiled gradient-echo MR imaging of the abdominal aorta and visceral and iliac vessels. Radiographics. 1997;17(2):423-432.
46. Holland GA, Dougherty L, Carpenter JP, et al. Breath-hold ultrafast three-dimensional gadolinium-enhanced MR angiography of the aorta and the renal and other visceral abdominal arteries. AJR Am J Roentgenol. 1996;166(4):971-981
47. Meaney JF, Prince MR, Nostrant TT, Stanley JC. Gadolinium-enhanced MR angiography of visceral arteries in patients with suspected chronic mesenteric ischemia. J Magn Reson Imaging. 7(1):171-6, 1997 Jan-Feb.
48. Shetty AS, Mellnick VM, Raptis C, Loch R, Owen J, Bhalla S. Limited utility of MRA for acute bowel ischemia after portal venous phase CT. Abdominal Imaging. 40(8):3020-8, 2015 Oct.Abdom Imaging. 40(8):3020-8, 2015 Oct.
49. Boley SJ, Sprayregan S, Siegelman SS, Veith FJ. Initial results from an agressive roentgenological and surgical approach to acute mesenteric ischemia. Surgery. 1977;82(6):848-855.
50. Boos S. [Angiography of the mesenteric artery 1976 to 1991. A change in the indications during mesenteric circulatory disorders?]. Radiologe. 1992;32(4):154-157.
51. Bottger T, Schafer W, Weber W, Junginger T. [Value of preoperative diagnosis in mesenteric vascular occlusion. A prospective study]. Langenbecks Arch Chir. 1990;375(5):278-282.
52. Clark RA, Gallant TE. Acute mesenteric ischemia: angiographic spectrum. AJR Am J Roentgenol. 1984;142(3):555-562.
53. Czerny M, Trubel W, Claeys L, et al. [Acute mesenteric ischemia]. Zentralbl Chir. 1997;122(7):538-544.
54. Kaufman SL, Harrington DP, Siegelman SS. Superior mesenteric artery embolization: an angiographic emergency. Radiology. 1977;124(3):625-630.
55. Marston A, Clarke JM, Garcia Garcia J, Miller AL. Intestinal function and intestinal blood supply: a 20 year surgical study. Gut. 1985;26(7):656-666.
56. Stoney RJ, Cunningham CG. Acute mesenteric ischemia. Surgery. 1993;114(3):489-490.
57. Brandt LJ, Boley SJ. AGA technical review on intestinal ischemia. American Gastrointestinal Association. Gastroenterology. 2000; 118(5):954-968.
58. Beaulieu RJ, Arnaoutakis KD, Abularrage CJ, Efron DT, Schneider E, Black JH, 3rd. Comparison of open and endovascular treatment of acute mesenteric ischemia. J Vasc Surg 2014;59:159-64.
59. Cai W, Li X, Shu C, et al. Comparison of clinical outcomes of endovascular versus open revascularization for chronic mesenteric ischemia: a meta-analysis. Ann Vasc Surg. 2015;29(5):934-940
60. Ryer EJ, Kalra M, Oderich GS, et al. Revascularization for acute mesenteric ischemia. J Vasc Surg 2012;55:1682-9.
61. Schermerhorn ML, Giles KA, Hamdan AD, Wyers MC, Pomposelli FB. Mesenteric revascularization: management and outcomes in the United States, 1988-2006. J Vasc Surg. 2009;50(2):341-348 e341.
62. Tallarita T, Oderich GS, Macedo TA, et al. Reinterventions for stent restenosis in patients treated for atherosclerotic mesenteric artery disease. J Vasc Surg. 2011;54(5):1422-1429 e1421
63. AbuRahma AF, Stone PA, Srivastava M, et al. Mesenteric/celiac duplex ultrasound interpretation criteria revisited. J Vasc Surg. 2012;55(2):428-436 e426; discussion 435-426
64. Moneta GL. Screening for mesenteric vascular insufficiency and follow-up of mesenteric artery bypass procedures. Semin Vasc Surg. 2001;14(3):186-192
65. Martinez JP, Hogan GJ. Mesenteric ischemia. Emerg Med Clin North Am. 2004;22(4):909-928
66. Schoots IG, Levi MM, Reekers JA, Lameris JS, van Gulik TM. Thrombolytic therapy for acute superior mesenteric artery occlusion. J Vasc Interv Radiol. 2005;16(3):317-329.
67. Harki J, Vergouwe Y, Spoor JA, et al. Diagnostic Accuracy of the Combination of Clinical Symptoms and CT or MR Angiography in Patients With Chronic Gastrointestinal Ischemia. J Clin Gastroenterol. 2016:[E-pub ahead of print]
68. Sun MY, Maykel JA. Ischemic colitis. Clin Colon Rectal Surg. 2007;20(1):5-12.
69. Karkkainen JM, Saari P, Kettunen HP, et al. Interpretation of Abdominal CT Findings in Patients Who Develop Acute on Chronic Mesenteric Ischemia. Journal of Gastrointestinal Surgery. 20(4):791-802, 2016 Apr.J Gastrointest Surg. 20(4):791-802, 2016 Apr.
70. Laissy JP, Trillaud H, Douek P. MR angiography: noninvasive vascular imaging of the abdomen. [Review] [74 refs]. Abdom Imaging. 27(5):488-506, 2002 Sep-Oct.
71. Steinmetz E, Tatou E, Favier-Blavoux C, et al. Endovascular treatment as first choice in chronic intestinal ischemia. Ann Vasc Surg. 2002; 16(6):693-699.
72. Hagspiel KD, Angle JF, Spinosa DJ, Matsumoto AH. Mesenteric ischemia: angiography and endovascular interventions. In: Long W, Peterson GJ, Jacobs DL, eds. Intestinal ischemia disorders: pathophysiology and management. St. Louis, MO: Quality Medical Publishing; 1999:105-154.
73. Arthurs ZM, Titus J, Bannazadeh M, et al. A comparison of endovascular revascularization with traditional therapy for the treatment of acute mesenteric ischemia. J Vasc Surg. 2011;53(3):698-704; discussion 704-695.
74. Di Minno MN, Milone F, Milone M, et al. Endovascular Thrombolysis in Acute Mesenteric Vein Thrombosis: a 3-year follow-up with the rate of short and long-term sequaelae in 32 patients. Thromb Res. 2010;126(4):295-298.
75. Zacharias N, Eghbalieh SD, Chang BB, et al. Chronic mesenteric ischemia outcome analysis and predictors of endovascular failure. Journal of Vascular Surgery. 63(6):1582-7, 2016 Jun.J Vasc Surg. 63(6):1582-7, 2016 Jun.
76. American College of Radiology. ACR Appropriateness Criteria® Radiation Dose Assessment Introduction. Available at: https://edge.sitecorecloud.io/americancoldf5f-acrorgf92a-productioncb02-3650/media/ACR/Files/Clinical/Appropriateness-Criteria/ACR-Appropriateness-Criteria-Radiation-Dose-Assessment-Introduction.pdf.
Disclaimer
The ACR Committee on Appropriateness Criteria and its expert panels have developed criteria for determining appropriate imaging examinations for diagnosis and treatment of specified medical condition(s). These criteria are intended to guide radiologists, radiation oncologists and referring physicians in making decisions regarding radiologic imaging and treatment. Generally, the complexity and severity of a patient’s clinical condition should dictate the selection of appropriate imaging procedures or treatments. Only those examinations generally used for evaluation of the patient’s condition are ranked.  Other imaging studies necessary to evaluate other co-existent diseases or other medical consequences of this condition are not considered in this document.  The availability of equipment or personnel may influence the selection of appropriate imaging procedures or treatments. Imaging techniques classified as investigational by the FDA have not been considered in developing these criteria; however, study of new equipment and applications should be encouraged.  The ultimate decision regarding the appropriateness of any specific radiologic examination or treatment must be made by the referring physician and radiologist in light of all the circumstances presented in an individual examination