Parathyroid Adenoma

Variant: 1 Adult or child. Primary hyperparathyroidism. Initial imaging.

Procedure	Appropriateness Category	Relative Radiation Level
US parathyroid	Usually Appropriate	O
Sestamibi scan and pertechnetate thyroid scan	Usually Appropriate
CT neck without and with IV contrast	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan neck	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
MRI neck with IV contrast	May Be Appropriate	O
MRI neck without and with IV contrast	May Be Appropriate	O
CT neck with IV contrast	May Be Appropriate	☢☢☢
Venous sampling parathyroid	Usually Not Appropriate	Varies
MRI neck without IV contrast	Usually Not Appropriate	O
CT neck without IV contrast	Usually Not Appropriate	☢☢☢

Variant: 2 Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.

Procedure	Appropriateness Category	Relative Radiation Level
US parathyroid	Usually Appropriate	O
Sestamibi scan and pertechnetate thyroid scan	Usually Appropriate
CT neck without and with IV contrast	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan neck	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Venous sampling parathyroid	May Be Appropriate	Varies
MRI neck with IV contrast	May Be Appropriate	O
MRI neck without and with IV contrast	May Be Appropriate	O
CT neck with IV contrast	May Be Appropriate	☢☢☢
MRI neck without IV contrast	Usually Not Appropriate	O
CT neck without IV contrast	Usually Not Appropriate	☢☢☢

Variant: 3 Adult or child. Secondary hyperparathyroidism. Initial imaging.

Procedure	Appropriateness Category	Relative Radiation Level
US parathyroid	Usually Appropriate	O
CT neck without and with IV contrast	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan neck	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and pertechnetate thyroid scan	May Be Appropriate (Disagreement)
MRI neck with IV contrast	May Be Appropriate	O
MRI neck without and with IV contrast	May Be Appropriate	O
CT neck with IV contrast	May Be Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan	May Be Appropriate (Disagreement)	☢☢☢
Venous sampling parathyroid	Usually Not Appropriate	Varies
MRI neck without IV contrast	Usually Not Appropriate	O
CT neck without IV contrast	Usually Not Appropriate	☢☢☢

Variant: 4 Adult or child. Tertiary hyperparathyroidism. Initial imaging.

Procedure	Appropriateness Category	Relative Radiation Level
US parathyroid	Usually Appropriate	O
Sestamibi scan and pertechnetate thyroid scan	Usually Appropriate
CT neck without and with IV contrast	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan neck	Usually Appropriate	☢☢☢
Sestamibi dual-phase scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck	Usually Appropriate	☢☢☢
MRI neck with IV contrast	May Be Appropriate	O
MRI neck without and with IV contrast	May Be Appropriate	O
CT neck with IV contrast	May Be Appropriate	☢☢☢
Sestamibi scan and I-123 thyroid scan	May Be Appropriate (Disagreement)	☢☢☢
Venous sampling parathyroid	Usually Not Appropriate	Varies
MRI neck without IV contrast	Usually Not Appropriate	O
CT neck without IV contrast	Usually Not Appropriate	☢☢☢

Panel Members

David Zander, MD^a; Paul M. Bunch, MD^b; Bruno Policeni, MD, MBA^c; Amy F. Juliano, MD^d; Denise Carneiro-Pla, MD^e; Prachi Dubey, MBBS, MPH^f; Maria K. Gule-Monroe, MD^g; Mari Hagiwara, MD^h; Kate DuChene Hanrahan, MD, MMEⁱ; Jenny K. Hoang, MBBS, MBA, MHS^j; Vikas Jain, MD^k; Lawrence T. Kim, MD^l; Gul Moonis, MD^m; Matthew S. Parsons, MDⁿ; Tanya J. Rath, MD^o; Carmen C. Solórzano, MD^p; Rathan M. Subramaniam, MD, PhD, MPH^q; M. Reza Taheri, MD, PhD^r; Andrew T. Trout, MD^s; Mark E. Zafereo Jr., MD^t; Amanda S. Corey, MD^u.

Summary of Literature Review

Introduction/Background

Initial Imaging Definition

Initial imaging is defined as imaging at the beginning of the care episode for the medical condition defined by the variant. More than one procedure can be considered usually appropriate in the initial imaging evaluation when:

There are procedures that are equivalent alternatives (i.e., only one procedure will be ordered to provide the clinical information to effectively manage the patient’s care)

There are complementary procedures (i.e., more than one procedure is ordered as a set or simultaneously wherein each procedure provides unique clinical information to effectively manage the patient’s care).

Special Imaging Considerations

Discussion of Procedures by Variant

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
A. CT neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
B. MRI neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
C. Sestamibi dual-phase scan neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
D. Sestamibi dual-phase scan with SPECT or SPECT/CT neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
E. Sestamibi scan and I-123 thyroid scan

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
F. Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
G. Sestamibi scan and pertechnetate thyroid scan

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
H. Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
I. US parathyroid

Variant 1: Adult or child. Primary hyperparathyroidism. Initial imaging.
J. Venous sampling parathyroid

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
A. CT neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
B. MRI neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
C. Sestamibi dual-phase scan neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
D. Sestamibi dual-phase scan with SPECT or SPECT/CT neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
E. Sestamibi scan and I-123 thyroid scan

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
F. Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
G. Sestamibi scan and pertechnetate thyroid scan

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
H. Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
I. US parathyroid

Variant 2: Adult or child. Primary hyperparathyroidism, recurrent or persistent after parathyroid surgery. Initial imaging.
J. Venous sampling parathyroid

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
A. CT neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
B. MRI neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
C. Sestamibi dual-phase scan neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
D. Sestamibi dual-phase scan with SPECT or SPECT/CT neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
E. Sestamibi scan and I-123 thyroid scan

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
F. Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
G. Sestamibi scan and pertechnetate thyroid scan

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
H. Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
I. US parathyroid

Variant 3: Adult or child. Secondary hyperparathyroidism. Initial imaging.
J. Venous sampling parathyroid

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
A. CT neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
B. MRI neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
C. Sestamibi dual-phase scan neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
D. Sestamibi dual-phase scan with SPECT or SPECT/CT neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
E. Sestamibi scan and I-123 thyroid scan

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
F. Sestamibi scan and I-123 thyroid scan with SPECT or SPECT/CT neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
G. Sestamibi scan and pertechnetate thyroid scan

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
H. Sestamibi scan and pertechnetate thyroid scan with SPECT or SPECT/CT neck

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
I. US parathyroid

Variant 4: Adult or child. Tertiary hyperparathyroidism. Initial imaging.
J. Venous sampling parathyroid

Summary of Highlights

Supporting Documents

The evidence table, literature search, and appendix for this topic are available at https://acsearch.acr.org/list. The appendix includes the strength of evidence assessment and the final rating round tabulations for each recommendation.

For additional information on the Appropriateness Criteria methodology and other supporting documents, please go to the ACR website at https://www.acr.org/Clinical-Resources/Clinical-Tools-and-Reference/Appropriateness-Criteria.

Appropriateness Category Names and Definitions

Appropriateness Category Name	Appropriateness Rating	Appropriateness Category Definition
Usually Appropriate	7, 8, or 9	The imaging procedure or treatment is indicated in the specified clinical scenarios at a favorable risk-benefit ratio for patients.
May Be Appropriate	4, 5, or 6	The imaging procedure or treatment may be indicated in the specified clinical scenarios as an alternative to imaging procedures or treatments with a more favorable risk-benefit ratio, or the risk-benefit ratio for patients is equivocal.
May Be Appropriate (Disagreement)	5	The individual ratings are too dispersed from the panel median. The different label provides transparency regarding the panel’s recommendation. “May be appropriate” is the rating category and a rating of 5 is assigned.
Usually Not Appropriate	1, 2, or 3	The imaging procedure or treatment is unlikely to be indicated in the specified clinical scenarios, or the risk-benefit ratio for patients is likely to be unfavorable.

Relative Radiation Level Information

Potential adverse health effects associated with radiation exposure are an important factor to consider when selecting the appropriate imaging procedure. Because there is a wide range of radiation exposures associated with different diagnostic procedures, a relative radiation level (RRL) indication has been included for each imaging examination. The RRLs are based on effective dose, which is a radiation dose quantity that is used to estimate population total radiation risk associated with an imaging procedure. Patients in the pediatric age group are at inherently higher risk from exposure, because of both organ sensitivity and longer life expectancy (relevant to the long latency that appears to accompany radiation exposure). For these reasons, the RRL dose estimate ranges for pediatric examinations are lower as compared with those specified for adults (see Table below). Additional information regarding radiation dose assessment for imaging examinations can be found in the ACR Appropriateness Criteria^® Radiation Dose Assessment Introduction document.

Relative Radiation Level Designations
Relative Radiation Level*	Adult Effective Dose Estimate Range	Pediatric Effective Dose Estimate Range
O	0 mSv	0 mSv
☢	<0.1 mSv	<0.03 mSv
☢☢	0.1-1 mSv	0.03-0.3 mSv
☢☢☢	1-10 mSv	0.3-3 mSv
☢☢☢☢	10-30 mSv	3-10 mSv
☢☢☢☢☢	30-100 mSv	10-30 mSv
*RRL assignments for some of the examinations cannot be made, because the actual patient doses in these procedures vary as a function of a number of factors (e.g., region of the body exposed to ionizing radiation, the imaging guidance that is used). The RRLs for these examinations are designated as “Varies.”

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Disclaimer

The ACR Committee on Appropriateness Criteria and its expert panels have developed criteria for determining appropriate imaging examinations for diagnosis and treatment of specified medical condition(s). These criteria are intended to guide radiologists, radiation oncologists and referring physicians in making decisions regarding radiologic imaging and treatment. Generally, the complexity and severity of a patient’s clinical condition should dictate the selection of appropriate imaging procedures or treatments. Only those examinations generally used for evaluation of the patient’s condition are ranked. Other imaging studies necessary to evaluate other co-existent diseases or other medical consequences of this condition are not considered in this document. The availability of equipment or personnel may influence the selection of appropriate imaging procedures or treatments. Imaging techniques classified as investigational by the FDA have not been considered in developing these criteria; however, study of new equipment and applications should be encouraged. The ultimate decision regarding the appropriateness of any specific radiologic examination or treatment must be made by the referring physician and radiologist in light of all the circumstances presented in an individual examination.