ACR–ACNM–SNMMI PRACTICE PARAMETER FOR THE PERFORMANCE OF DOPAMINE TRANSPORTER (DaT) SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) IMAGING FOR MOVEMENT DISORDERS

PREAMBLE

INTRODUCTION

II.

INDICATIONS AND CONTRAINDICATIONS

III.

QUALIFICATIONS AND RESPONSIBILITIES OF PERSONNEL

IV.

SPECIFICATIONS OF THE EXAMINATION

IV.

SPECIFICATIONS OF THE EXAMINATION

Nuclear Medicine Examination Request

IV.

SPECIFICATIONS OF THE EXAMINATION

Radiopharmaceutical

IV.

SPECIFICATIONS OF THE EXAMINATION

Patient Preparation

Prearrival

IV.

SPECIFICATIONS OF THE EXAMINATION

Patient Preparation

Preinjection

IV.

SPECIFICATIONS OF THE EXAMINATION

Image Acquisition

Timing

IV.

SPECIFICATIONS OF THE EXAMINATION

Image Acquisition

Patient Positioning

IV.

SPECIFICATIONS OF THE EXAMINATION

Image Acquisition

Image Protocol

IV.

SPECIFICATIONS OF THE EXAMINATION

Data Processing

Reconstruction

IV.

SPECIFICATIONS OF THE EXAMINATION

Data Processing

Filtering

IV.

SPECIFICATIONS OF THE EXAMINATION

Data Processing

Attenuation

IV.

SPECIFICATIONS OF THE EXAMINATION

Data Processing

Quantification

IV.

SPECIFICATIONS OF THE EXAMINATION

Image Interpretation

Qualitative

IV.

SPECIFICATIONS OF THE EXAMINATION

Image Interpretation

Quantitative

DOCUMENTATION

VI.

EQUIPMENT SPECIFICATIONS

VII.

RADIATION SAFETY IN IMAGING

VIII.

QUALITY CONTROL AND IMPROVEMENT, SAFETY, INFECTION CONTROL, AND PATIENT EDUCATION

ACKNOWLEDGEMENTS

REFERENCES

1. American College of Radiology. ACR–ACNM–SNMMI–SPR Practice Parameter for the Use of Radiopharmaceuticals in Diagnostic Procedures. Available at https://gravitas.acr.org/PPTS/GetDocumentView?docId=171+&releaseId=2
2. Banks KP, Peacock JG, Clemenshaw MN, Kuo PH. Optimizing the Diagnosis of Parkinsonian Syndromes With 123I-Ioflupane Brain SPECT. AJR Am J Roentgenol. 2019 Aug;213(2):243-253.
3. Kwakye GF, Paoliello MM, Mukhopadhyay S, Bowman AB, Aschner M. Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. Int J Environ Res Public Health. 2015 Jul 06;12(7):7519-40.
4. de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol. 2006 Jun;5(6):525-35.
5. Nussbaum RL, Ellis CE. Alzheimer's disease and Parkinson's disease. N Engl J Med. 2003 Apr 03;348(14):1356-64.
6. Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord. 2003 Jan;18(1):19-31.
7. Bennett DA, Beckett LA, Murray AM, et al. Prevalence of parkinsonian signs and associated mortality in a community population of older people. N Engl J Med. 1996 Jan 11;334(2):71-6.
8. Hughes AJ, Daniel SE, Ben-Shlomo Y, Lees AJ. The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain. 2002 Apr;125(Pt 4):861-70.
9. Bega D, Kuo PH, Chalkidou A, et al. Clinical utility of DaTscan in patients with suspected Parkinsonian syndrome: a systematic review and meta-analysis. NPJ Parkinsons Dis. 2021 May 24;7(1):43.
10. Coarelli G, Garcin B, Roze E, Vidailhet M, Degos B. Invalidation of Parkinson's disease diagnosis after years of follow-up based on clinical, radiological and neurophysiological examination. J Neurol Sci. 2019 Nov 15;406():S0022-510X(19)30386-7.
11. Isaacson SH, Fisher S, Gupta F, et al. Clinical utility of DaTscan™ imaging in the evaluation of patients with parkinsonism: a US perspective. Expert Rev Neurother. 2017 Mar;17(3):219-225.
12. Cohen O, Pullman S, Jurewicz E, Watner D, Louis ED. Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics. Arch Neurol. 2003 Mar;60(3):405-10.
13. Louis ED, Wendt KJ, Pullman SL, Ford B. Is essential tremor symmetric? Observational data from a community-based study of essential tremor. Arch Neurol. 1998 Dec;55(12):1553-9.
14. Meara J, Bhowmick BK, Hobson P. Accuracy of diagnosis in patients with presumed Parkinson's disease. Age Ageing. 1999 Mar;28(2):99-102.
15. Palermo G, Ceravolo R. Molecular Imaging of the Dopamine Transporter. Cells. 2019 Aug 10;8(8):872.
16. Booij J, Andringa G, Rijks LJ, et al. [123I]FP-CIT binds to the dopamine transporter as assessed by biodistribution studies in rats and SPECT studies in MPTP-lesioned monkeys. Synapse. 1997 Nov;27(3):183-90.
17. Catafau AM, Tolosa E, Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes. Mov Disord. 2004 Oct;19(10):1175-82.
18. GE Healthcare. Quality Checks; Section 2.5. Protocol Manual - DaTScan;; 2011.
19. Ikeda K, Ebina J, Kawabe K, Iwasaki Y. Dopamine Transporter Imaging in Parkinson Disease: Progressive Changes and Therapeutic Modification after Anti-parkinsonian Medications. Intern Med. 2019 Jun 15;58(12):1665-1672.
20. Brigo F, Matinella A, Erro R, Tinazzi M. [¹²³I]FP-CIT SPECT (DaTSCAN) may be a useful tool to differentiate between Parkinson's disease and vascular or drug-induced parkinsonisms: a meta-analysis. Eur J Neurol. 2014 Nov;21(11):1369-e90.
21. Gayed I, Joseph U, Fanous M, et al. The impact of DaTscan in the diagnosis of Parkinson disease. Clin Nucl Med. 2015 May;40(5):390-3.
22. Liu R, Umbach DM, Troster AI, Huang X, Chen H. Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease. Parkinsonism & Related Disorders. 72:23-30, 2020 03.
23. Massa J, Chahine LM. Revision of Diagnosis in Early Parkinsonism with Abnormal Dopamine Transporter Imaging. Journal of Parkinsons Disease Print. 9(2):327-334, 2019.J Parkinsons Dis. 9(2):327-334, 2019.
24. Noyce AJ, Dickson J, Rees RN, et al. Dopamine reuptake transporter-single-photon emission computed tomography and transcranial sonography as imaging markers of prediagnostic Parkinson's disease. Mov Disord. 33(3):478-482, 2018 03.
25. National Center for Biotechnology Information. Ioflupane I-123. Available at: https://www.ncbi.nlm.nih.gov/books/NBK501915/. .
26. American College of Radiology. ACR-SPR Practice Parameter for Imaging Pregnant or Potentially Pregnant Patients with Ionizing Radiation. Available at: https://gravitas.acr.org/PPTS/GetDocumentView?docId=23+&releaseId=2.
27. American College of Radiology. ACR Practice Parameter for Continuing Medical Education. Available at https://gravitas.acr.org/PPTS/GetDocumentView?docId=130+&releaseId=2
28. American College of Radiology. ACR-AAPM Technical Standard for Medical Physics Performance Monitoring of Spect-CT Equipment. Available at https://www.acr.org/-/media/ACR/Files/Practice-Parameters/SPECT-CT-Equip.pdf.
29. American College of Radiology. ACR–SPR Practice Parameter for Performing and Interpreting Diagnostic Computed Tomography (CT). Available at https://gravitas.acr.org/PPTS/GetDocumentView?docId=132+&releaseId=2
30. Booij J, Kemp P. Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs. Eur J Nucl Med Mol Imaging. 2008 Feb;35(2):424-38.
31. Frankl JA, Bose S, Kuo PH. False-Positive Findings on Dopamine Transporter SPECT Due to Therapeutic Dextroamphetamine and Amphetamine. J Nucl Med Technol. 2018 Jun;46(2):149-150.
32. Shang Y, Gibbs MA, Marek GJ, et al. Displacement of serotonin and dopamine transporters by venlafaxine extended release capsule at steady state: a [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane single photon emission computed tomography imaging study. J Clin Psychopharmacol. 2007 Feb;27(1):71-5.
33. Booij J, de Jong J, de Bruin K, Knol R, de Win MM, van Eck-Smit BL. Quantification of striatal dopamine transporters with 123I-FP-CIT SPECT is influenced by the selective serotonin reuptake inhibitor paroxetine: a double-blind, placebo-controlled, crossover study in healthy control subjects. J Nucl Med. 2007 Mar;48(3):359-66.
34. Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 09;351(24):2498-508.
35. Janicek AK, Avery RJ, Kuo PH. The pinwheel sign: artifact from head rotation during SPECT acquisition for dopamine transporter imaging. J Nucl Med Technol. 2014 Mar;42(1):75-6.
36. Covington MF, McMillan NA, Avery RJ, Kuo PH. The semicolon sign: dopamine transporter imaging artifact from head tilt. J Nucl Med Technol. 2013 Jun;41(2):105-7.
37. Koch W, Hamann C, Welsch J, Pöpperl G, Radau PE, Tatsch K. Is iterative reconstruction an alternative to filtered backprojection in routine processing of dopamine transporter SPECT studies?. J Nucl Med. 2005 Nov;46(11):1804-11.
38. Morano GN, Seibyl JP. Technical overview of brain SPECT imaging: improving acquisition and processing of data. J Nucl Med Technol. 2003 Dec;31(4):191-5; quiz 202-3.
39. Dickson JC, Tossici-Bolt L, Sera T, et al. The impact of reconstruction method on the quantification of DaTSCAN images. Eur J Nucl Med Mol Imaging. 2010 Jan;37(1):23-35.
40. Soret M, Koulibaly PM, Darcourt J, Hapdey S, Buvat I. Quantitative accuracy of dopaminergic neurotransmission imaging with (123)I SPECT. J Nucl Med. 2003 Jul;44(7):1184-93.
41. Jarritt PH, Whalley DR, Skrypniuk JV, Houston AS, Fleming JS, Cosgriff PS. UK audit of single photon emission computed tomography reconstruction software using software generated phantoms. Nucl Med Commun. 2002 May;23(5):483-91.
42. Habraken JB, Booij J, Slomka P, Sokole EB, van Royen EA. Quantification and visualization of defects of the functional dopaminergic system using an automatic algorithm. J Nucl Med. 1999 Jul;40(7):1091-7.
43. Kuo PH, Eshghi N, Tinaz S, Blumenfeld H, Louis ED, Zubal G. Optimization of Parameters for Quantitative Analysis of 123I-Ioflupane SPECT Images for Monitoring Progression of Parkinson Disease. J Nucl Med Technol. 2019 Mar;47(1):70-74.
44. Badiavas K, Molyvda E, Iakovou I, Tsolaki M, Psarrakos K, Karatzas N. SPECT imaging evaluation in movement disorders: far beyond visual assessment. Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):764-73.
45. Yokoyama K, Imabayashi E, Sumida K, et al. Computed-tomography-guided anatomic standardization for quantitative assessment of dopamine transporter SPECT. Eur J Nucl Med Mol Imaging. 2017 Mar;44(3):366-372.
46. Mushtaq R, Kay MD, Steinmeyer L, Warhadpande D, Kuo PH. Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT. Clin Nucl Med. 2020 Nov;45(11):e469-e476.
47. Booij J, Dubroff J, Pryma D, et al. Diagnostic Performance of the Visual Reading of 123I-Ioflupane SPECT Images With or Without Quantification in Patients With Movement Disorders or Dementia. J Nucl Med. 2017 Nov;58(11):1821-1826.
48. American College of Radiology. ACR Practice Parameter for Communication of Diagnostic Imaging Findings. Available at https://gravitas.acr.org/PPTS/GetDocumentView?docId=74+&releaseId=2